Although DNA is the carrier of genetic information, it has limited chemical stability.
Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant rates in vivo …

Cold Spring Harbor Symposia on Quantitative Biology, Volume LXV.© 2000 Cold Spring
Harbor Laboratory Press 0-87969-605-2/00. 127 bile glycosyl bond of 7 …

The complete sequence of honeybee (Apis mellifera) mitochondrial DNA is reported being
16,343 bp long in the strain sequenced. Relative to their positions in the Drosophila map, 11 …

The basic mechanisms of antibacterial resistance are well known, but critical new aspects
continue to be discovered. Recently discovered factors with major implications for the …

Methylating agents generate cytotoxic and mutagenic DNA damage. Cells use 3-
methyladenine-DNA glycosylases to excise some methylated bases from DNA, and suicidal …

Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and
survive these stresses, bacteria have global response systems that result in sweeping …

▪ Abstract The biological impact of any DNA damaging agent is a combined function of the
chemical nature of the induced lesions and the efficiency and accuracy of their repair …

Publisher Summary This chapter focuses on the structure and function of alkyltransferase
protein. O 6-alkylguanine-DNA alkyltransferase is a remarkable protein that alone can, in a …

Mutation rates are generally thought not to be influenced by selective forces. This doctrine
rests on the results of certain classical studies of the mutations that make bacteria resistant …

Methylating agents modify DNA at many different sites, thereby producing lethal and
mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA …