Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low
testosterone levels are associated with increased fat mass (particularly central adiposity) …

Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose
substantial diagnostic challenges, as many patients are still misdiagnosed, or remain …

Background The novel severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)
disease 2019 (COVID‐19) seems to have a worse clinical course among infected men …

Male hypogonadism (MH) is a common endocrine disorder. However, uncertainties and
variations in its diagnosis and management exist. There are several current guidelines on …

Obesity, type 2 diabetes mellitus and the metabolic syndrome are major risk factors for
cardiovascular disease. Studies have demonstrated an association between low levels of …

Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

Gender-associated differences in the development of cardiovascular diseases have been
described in humans and animals. These differences could explain the low incidence of …

Aim The goal of this study was to determine if long‐term testosterone (T) therapy in men with
hypogonadism, henceforth referred to as testosterone deficiency (TD), ameliorates or …

Objectives: In the absence of large, prospective, placebo-controlled studies of longer
duration, substantial evidence regarding the safety and risk of testosterone (T) therapy (TTh) …

Considerable research has shown that testosterone regulates many physiological systems,
modulates clinical disorders, and contributes to health outcome. However, studies on the …