Targeting USP22 suppresses tumorigenicity and enhances cisplatin sensitivity through ALDH1A3 downregulation in cancer-initiating cells from lung adenocarcinoma
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-
differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated …
differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated …
Loss of H2B monoubiquitination is associated with poor‐differentiation and enhanced malignancy of lung adenocarcinoma
Deregulated monoubiquitination of histone H2B (H2Bub1), mainly catalyzed by E3 ubiquitin‐
protein ligase RNF20/RNF40 complex, may play an important role in cancer. Here we …
protein ligase RNF20/RNF40 complex, may play an important role in cancer. Here we …
The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) …
Enzymatic factors driving cancer-associated chromatin remodelling are of increasing interest
as the role of the cancer epigenome in gene expression and DNA repair processes …
as the role of the cancer epigenome in gene expression and DNA repair processes …
[HTML][HTML] H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription
S Nagarajan, E Benito, A Fischer, SA Johnsen - Oncotarget, 2015 - ncbi.nlm.nih.gov
Hormone-dependent gene expression requires dynamic and coordinated epigenetic
changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon …
changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon …
let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery
Monoubiquitylation of histone H2B (H2Bub1) is catalyzed mainly by the RNF20/RNF40
complex and erased by multiple deubiquitylating enzymes (DUBs). H2Bub1 influences …
complex and erased by multiple deubiquitylating enzymes (DUBs). H2Bub1 influences …
A quantitative chemical proteomics approach for site‐specific stoichiometry analysis of ubiquitination
Stoichiometric analysis of post‐translational modifications is an emerging strategy for
absolute quantification of the fractional abundance of the modification. Herein, a quantitative …
absolute quantification of the fractional abundance of the modification. Herein, a quantitative …
Comparative proteomics of dying and surviving cancer cells improves the identification of drug targets and sheds light on cell life/death decisions
Chemotherapeutics cause the detachment and death of adherent cancer cells. When
studying the proteome changes to determine the protein target and mechanism of action of …
studying the proteome changes to determine the protein target and mechanism of action of …
The M ediator subunit MED 23 couples H2B mono‐ubiquitination to transcriptional control and cell fate determination
X Yao, Z Tang, X Fu, J Yin, Y Liang, C Li, H Li… - The EMBO …, 2015 - embopress.org
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for
precise transcriptional control. However, its interplay with the surrounding chromatin …
precise transcriptional control. However, its interplay with the surrounding chromatin …
Structure and function of the RING domains of RNF20 and RNF40, dimeric E3 ligases that monoubiquitylate histone H2B
Monoubiquitylation of histone H2B is a post-translational mark that plays key roles in
regulation of transcription and genome stability. In humans, attachment of ubiquitin to lysine …
regulation of transcription and genome stability. In humans, attachment of ubiquitin to lysine …
Role of H2B mono-ubiquitination in the initiation and progression of cancer
S Zhou, Y Cai, X Liu, L Jin, X Wang, W Ma, T Zhang - Bulletin du Cancer, 2021 - Elsevier
Numerous epigenetic alterations are observed in cancer cells, and dysregulation of mono-
ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a …
ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a …