The histone methyltransferase enhancer of zeste 2 (EZH2) is known to be a polycomb
protein homologous to Drosophila enhancer of zeste and catalyzes the addition of methyl …

Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires a
resetting of the epigenome in order to facilitate a cell fate transition. Previous studies have …

Epigenetic regulatory mechanisms play a central role in controlling gene expression during
development, cell differentiation and tumorigenesis. Monoubiquitination of histone H2B is …

Mono-ubiquitination on H2B (H2Bub1) is an evolutionarily conserved histone post-
translational modification implicated in various important physiological processes including …

People are exposed to wide range of redox-active environmental pollutants. Air pollution,
heavy metals, pesticides, and endocrine disrupting chemicals can disrupt cellular redox …

Cyclin-dependent kinase-9 (CDK9) plays a central role in transcriptional elongation and
controls multiple cotranscriptional histone modifications, including histone H2B …

Histone H2B ubiquitination mediated by the Rad6/Bre1 complex is crucial for regulating the
stability and reassembly of the nucleosome. To understand the regulatory mechanisms of …

The molecular mechanisms regulating oestrogen homeostasis have been primarily studied
in the mammary gland, which is the focus of this review. In the non‐pregnant adult, the …

Posttranslational histone modifications play important roles in regulating chromatin structure
and transcriptional regulation. Histone H2B monoubiquitination (H2Bub) is an essential …

Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs
is considered as a novel anticancer therapeutic strategy. Overexpression of ubiquitin …