When transcribed DNA is damaged, the transcription and DNA repair machineries must
interact to ensure successful DNA repair. The mechanisms of this interaction in the context of …

Gene expression is thought to be affected not only by the concentration of transcription
factors (TFs) but also the dynamics of their nuclear translocation. Testing this hypothesis …

Aging and age-related diseases pose some of the most significant and difficult challenges to
modern society as well as to the scientific and medical communities. Biological aging is a …

In yeast, heterochromatin silencing is reported to decline in aging mother cells, causing
sterility in old cells. This process is thought to reflect a decrease in the activity of the NAD+ …

Emerging evidence indicates that epigenetic regulators are critically required for the
maintenance of tissue-specific stem cells and that the epigenetic marks are altered in stem …

Epigenomic changes and stem cell deterioration are two hallmarks of aging. Accumulating
evidence suggest that senescence of mesenchymal stromal cells (MSCs) perpetuates aging …

Alzheimer's dementia commonly impacts the health of older adults and lacks any
preventative therapy. While Alzheimer's dementia risk has a substantial genetic component …

Recently, various studies have shown that epigenetic changes are associated with aging
and age‐related diseases. Both animal and human models have revealed that epigenetic …

All living things experience entropy, manifested as a loss of inherited genetic and epigenetic
information over time. As budding yeast cells age, epigenetic changes result in a loss of cell …

The current understanding of how specific distributions of histone post-translational
modifications (PTMs) are achieved throughout the chromatin remains incomplete. This …