Metformin: historical overview

CJ Bailey - Diabetologia, 2017 - Springer
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-
lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also …

Metformin: clinical use in type 2 diabetes

E Sanchez-Rangel, SE Inzucchi - Diabetologia, 2017 - Springer
Metformin is one of the most popular oral glucose-lowering medications, widely considered
to be the optimal initial therapy for patients with type 2 diabetes mellitus. Interestingly, there …

Treatment of diabetes in older adults: an Endocrine Society clinical practice guideline

D LeRoith, GJ Biessels, SS Braithwaite… - The Journal of …, 2019 - academic.oup.com
Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …

Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update …

A Qaseem, TJ Wilt, D Kansagara… - Annals of internal …, 2018 - acpjournals.org
Description: The American College of Physicians developed this guidance statement to
guide clinicians in selecting targets for pharmacologic treatment of type 2 diabetes. Methods …

Potential impact of the multi-target drug approach in the treatment of some complex diseases

XH Makhoba, C Viegas Jr, RA Mosa… - Drug design …, 2020 - Taylor & Francis
It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

[HTML][HTML] 2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension

TD Wang, CE Chiang, TH Chao, HM Cheng… - Acta Cardiologica …, 2022 - ncbi.nlm.nih.gov
Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

Type 2 diabetes in the real world: the elusive nature of glycemic control

SV Edelman, WH Polonsky - Diabetes care, 2017 - Am Diabetes Assoc
Despite US Food and Drug Administration (FDA) approval of over 40 new treatment options
for type 2 diabetes since 2005, the latest data from the National Health and Nutrition …

Preparation of bioactive peptides with antidiabetic, antihypertensive, and antioxidant activities and identification of α‐glucosidase inhibitory peptides from soy protein

R Wang, H Zhao, X Pan, C Orfila, W Lu… - Food science & …, 2019 - Wiley Online Library
In this study, the peptides of soy protein obtained by enzymatic digestion with proteases
were analyzed for their antidiabetic, antihypertensive, and antioxidant activities. Peptides …

Newer pharmacologic treatments in adults with type 2 diabetes: a systematic review and network meta-analysis for the American College of Physicians

T Drake, A Landsteiner, L Langsetmo… - Annals of internal …, 2024 - acpjournals.org
Background: Newer diabetes medications may have beneficial effects on mortality,
cardiovascular outcomes, and renal outcomes. Purpose: To evaluate the effectiveness …

An updated review on food‐derived bioactive peptides: Focus on the regulatory requirements, safety, and bioavailability

PJ Patil, M Usman, C Zhang… - … Reviews in Food …, 2022 - Wiley Online Library
Food‐derived bioactive peptides (BAPs) are recently utilized as functional food raw
materials owing to their potential health benefits. Although there is a huge amount of …