Promoter shape varies across populations and affects promoter evolution and expression noise
Animal promoters initiate transcription either at precise positions (narrow promoters) or
dispersed regions (broad promoters), a distinction referred to as promoter shape. Although …
dispersed regions (broad promoters), a distinction referred to as promoter shape. Although …
[HTML][HTML] Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability
The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was
contradicted by the identification of capped transcripts missing portions of their 5′ ends and …
contradicted by the identification of capped transcripts missing portions of their 5′ ends and …
Identification of an ABCB1 (P‐glycoprotein)‐positive carfilzomib‐resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1
TS Hawley, I Riz, W Yang… - American journal of …, 2013 - Wiley Online Library
Multiple myeloma (MM) is characterized by the malignant expansion of differentiated plasma
cells. Although many chemotherapeutic agents display cytotoxic activity toward MM cells …
cells. Although many chemotherapeutic agents display cytotoxic activity toward MM cells …
GT‐rich promoters can drive RNA pol II transcription and deposition of H2A. Z in African trypanosomes
C Wedel, KU Förstner, R Derr, TN Siegel - The EMBO journal, 2017 - embopress.org
Genome‐wide transcription studies are revealing an increasing number of “dispersed
promoters” that, unlike “focused promoters”, lack well‐conserved sequence motifs and tight …
promoters” that, unlike “focused promoters”, lack well‐conserved sequence motifs and tight …
ElemeNT: a computational tool for detecting core promoter elements
Core promoter elements play a pivotal role in the transcriptional output, yet they are often
detected manually within sequences of interest. Here, we present 2 contributions to the …
detected manually within sequences of interest. Here, we present 2 contributions to the …
Absence of canonical marks of active chromatin in developmentally regulated genes
The interplay of active and repressive histone modifications is assumed to have a key role in
the regulation of gene expression. In contrast to this generally accepted view, we show that …
the regulation of gene expression. In contrast to this generally accepted view, we show that …
The NSL Complex Regulates Housekeeping Genes in Drosophila
MOF is the major histone H4 lysine 16-specific (H4K16) acetyltransferase in mammals and
Drosophila. In flies, it is involved in the regulation of X-chromosomal and autosomal genes …
Drosophila. In flies, it is involved in the regulation of X-chromosomal and autosomal genes …
RAMPAGE: Promoter Activity Profiling by Paired‐End Sequencing of 5′‐Complete cDNAs
P Batut, TR Gingeras - Current protocols in molecular biology, 2013 - Wiley Online Library
RNA annotation and mapping of promoters for analysis of gene expression (RAMPAGE) is a
method that harnesses highly specific sequencing of 5′‐complete complementary DNAs to …
method that harnesses highly specific sequencing of 5′‐complete complementary DNAs to …
[HTML][HTML] Regulation of gene expression in the genomic context
TJ Atkinson, MS Halfon - Computational and structural biotechnology …, 2014 - Elsevier
Metazoan life is dependent on the proper temporal and spatial control of gene expression
within the many cells—essentially all with the identical genome—that make up the organism …
within the many cells—essentially all with the identical genome—that make up the organism …
The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
The MOF (males absent on the first)-containing NSL (non-specific lethal) complex binds to a
subset of active promoters in Drosophila melanogaster and is thought to contribute to proper …
subset of active promoters in Drosophila melanogaster and is thought to contribute to proper …