Advancing Sustainable Peptide Synthesis by Solvent Quality Control: Understanding and Mitigating Hydroperoxide in 1-Butyl-2-pyrrolidinone (NBP)
J Pawlas, TM El-Dine, K Bargen, C Bargen… - … Process Research & …, 2024 - ACS Publications
While numerous studies aimed at producing peptides in a sustainable manner have recently
been reported, the impact of the quality of starting materials on sustainability in peptide …
been reported, the impact of the quality of starting materials on sustainability in peptide …
Exploring the Potential Impact of GLP-1 Receptor Agonists on Substance Use, Compulsive Behavior, and Libido: Insights from Social Media Using a Mixed-Methods …
D Arillotta, G Floresta, GD Papanti Pelletier, A Guirguis… - Brain Sciences, 2024 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is involved in a range of central and peripheral pathways
related to appetitive behavior. Hence, this study explored the effects of glucagon-like peptide …
related to appetitive behavior. Hence, this study explored the effects of glucagon-like peptide …
Encouraging mortality trends among the obese population in England, but public health challenges from rising obesity prevalence remain
T Adair - The Lancet Regional Health–Europe, 2024 - thelancet.com
The increase in obesity prevalence has been a leading public health concern in many high-
income countries in recent decades. Obesity has been widely found to increase the risk of …
income countries in recent decades. Obesity has been widely found to increase the risk of …
An Exhaustive Exploration of the Semaglutide-GLP-1R Sequence Space towards the Design of Semaglutide Analogues with Elevated Binding Affinity to GLP-1R
W Li - 2024 - preprints.org
Semaglutide is a potent GLP-1 receptor agonist used in the treatment of type 2 diabetes
mellitus due to its ability to regulate blood glucose levels and promote weight loss. On July …
mellitus due to its ability to regulate blood glucose levels and promote weight loss. On July …
Optimizing GLP-1R Agonist: A Computational Semaglutide Analogue with 112-fold Enhanced Binding Affinity to GLP-1R
W Li - 2024 - preprints.org
Drug-target binding is a crucial parameter in drug discovery and design, ensuring drug
efficacy and specificity. Semaglutide, a potent GLP-1 receptor agonist, is widely used to treat …
efficacy and specificity. Semaglutide, a potent GLP-1 receptor agonist, is widely used to treat …
Inter-molecular Binding Affinity Synthetic Data Augmentation Transforms the Landscape of Computational Biomolecule Design and Discovery
W Li - 2024 - preprints.org
The advancement of computational drug discovery and design necessitates continuous
innovation to enhance the accuracy and scope of predictive models for early-stage drug …
innovation to enhance the accuracy and scope of predictive models for early-stage drug …