Long Covid: where we stand and challenges ahead

A Mantovani, MC Morrone, C Patrono… - Cell Death & …, 2022 - nature.com
Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and
colloquially as Long Covid, has been defined as a constellation of signs and symptoms …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena… - Cell host & …, 2022 - cell.com
SARS-CoV-2 lineages have diverged into highly prevalent variants termed" variants of
concern"(VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in …

SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation

MM Rajah, M Hubert, E Bishop, N Saunders… - The EMBO …, 2021 - embopress.org
Severe COVID‐19 is characterized by lung abnormalities, including the presence of
syncytial pneumocytes. Syncytia form when SARS‐CoV‐2 spike protein expressed on the …

SARS-CoV-2: a master of immune evasion

A Rubio-Casillas, EM Redwan, VN Uversky - Biomedicines, 2022 - mdpi.com
Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

Long-term effects of SARS-CoV-2 infection on human brain and memory

Q Ding, HJ Zhao - Cell Death Discovery, 2023 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have caused
several waves of outbreaks. From the ancestral strain to Omicron variant, SARS-CoV-2 has …

Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

MC Chiu, C Li, X Liu, Y Yu, J Huang, Z Wan, D Xiao… - Cell discovery, 2022 - nature.com
The airways and alveoli of the human respiratory tract are lined by two distinct types of
epithelium, which are the primary targets of respiratory viruses. We previously established …

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

H Ren, C Ma, H Peng, B Zhang, L Zhou, Y Su, X Gao… - Biology Direct, 2021 - Springer
SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to
dysregulated immune activation and extensive lung tissue damage. However, the …

IFITM protein regulation and functions: Far beyond the fight against viruses

N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …