mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer

RR Malla, M Srilatha, B Farran, GP Nagaraju - Molecular Therapy, 2024 - cell.com
mRNA vaccines have evolved as promising cancer therapies. These vaccines can encode
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …

Emerging delivery approaches for targeted pulmonary fibrosis treatment

R Diwan, HN Bhatt, E Beaven, M Nurunnabi - Advanced drug delivery …, 2023 - Elsevier
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Y Tang, B Liu, Y Zhang, Y Liu, Y Huang… - Advanced Drug Delivery …, 2024 - Elsevier
The lymphatic system has garnered significant attention in drug delivery research due to the
advantages it offers, such as enhancing systemic exposure and enabling lymph node …

mRNA delivery systems for cancer immunotherapy: lipid nanoparticles and beyond

ME Senti, LG Del Valle, RM Schiffelers - Advanced Drug Delivery Reviews, 2024 - Elsevier
Abstract mRNA-based vaccines are emerging as a promising alternative to standard cancer
treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid …

Rational design of ICD-inducing nanoparticles for cancer immunotherapy

Z Zhang, Z Pan, Q Li, Q Huang, L Shi, Y Liu - Science Advances, 2024 - science.org
Nanoparticle-based cancer immunotherapy has shown promising therapeutic potential in
clinical settings. However, current research mainly uses nanoparticles as delivery vehicles …

The potential of mRNA vaccines in cancer nanomedicine and immunotherapy

S Pan, R Fan, B Han, A Tong, G Guo - Trends in Immunology, 2024 - cell.com
Owing to their outstanding performance against COVID-19, mRNA vaccines have brought
great hope for combating various incurable diseases, including cancer. Differences in the …

[HTML][HTML] Engineering LNPs with polysarcosine lipids for mRNA delivery

DD Kang, X Hou, L Wang, Y Xue, H Li, Y Zhong… - Bioactive Materials, 2024 - Elsevier
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-
2 virus, there has been an increased interest in the delivery of mRNA through LNPs …

Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length

K Mrksich, MS Padilla, RA Joseph… - … Research Part A, 2024 - Wiley Online Library
RNA‐based therapeutics have gained traction for the prevention and treatment of a variety
of diseases. However, their fragility and immunogenicity necessitate a drug carrier. Lipid …

Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry

B Li, IO Raji, AGR Gordon, L Sun, TM Raimondo… - Nature Materials, 2024 - nature.com
To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid
nanoparticles is paramount. However, a pivotal component of lipid nanoparticle …

mRNA vaccine designs for optimal adjuvanticity and delivery

Y Mochida, S Uchida - RNA biology, 2024 - Taylor & Francis
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA
vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the …