Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
Y Tang, B Liu, Y Zhang, Y Liu, Y Huang… - Advanced Drug Delivery …, 2024 - Elsevier
The lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node …
ME Senti, LG Del Valle, RM Schiffelers - Advanced Drug Delivery Reviews, 2024 - Elsevier
Abstract mRNA-based vaccines are emerging as a promising alternative to standard cancer treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid …
Z Zhang, Z Pan, Q Li, Q Huang, L Shi, Y Liu - Science Advances, 2024 - science.org
Nanoparticle-based cancer immunotherapy has shown promising therapeutic potential in clinical settings. However, current research mainly uses nanoparticles as delivery vehicles …
S Pan, R Fan, B Han, A Tong, G Guo - Trends in Immunology, 2024 - cell.com
Owing to their outstanding performance against COVID-19, mRNA vaccines have brought great hope for combating various incurable diseases, including cancer. Differences in the …
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV- 2 virus, there has been an increased interest in the delivery of mRNA through LNPs …
K Mrksich, MS Padilla, RA Joseph… - … Research Part A, 2024 - Wiley Online Library
RNA‐based therapeutics have gained traction for the prevention and treatment of a variety of diseases. However, their fragility and immunogenicity necessitate a drug carrier. Lipid …
B Li, IO Raji, AGR Gordon, L Sun, TM Raimondo… - Nature Materials, 2024 - nature.com
To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid nanoparticle …
Y Mochida, S Uchida - RNA biology, 2024 - Taylor & Francis
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the …