Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

The role of astrocyte in neuroinflammation in traumatic brain injury

L He, R Zhang, M Yang, M Lu - … et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Traumatic brain injury (TBI), a significant contributor to mortality and morbidity worldwide, is
a devastating condition characterized by initial mechanical damage followed by subsequent …

Treadmill exercise modulates intestinal microbes and suppresses LPS displacement to alleviate neuroinflammation in the brains of APP/PS1 mice

S Yuan, J Yang, Y Jian, Y Lei, S Yao, Z Hu, X Liu… - Nutrients, 2022 - mdpi.com
Neuroinflammation occurs throughout the pathogenesis of Alzheimer's disease (AD). Here,
we investigated the effects of treadmill exercise on neuroinflammation in APP/PS1 …

Drug discovery and development targeting dementia

A Zagórska, A Czopek, M Fryc, A Jaromin, BJ Boyd - Pharmaceuticals, 2023 - mdpi.com
Dementia, most often associated with neurodegenerative diseases, affects millions of
people worldwide, predominantly the elderly. Unfortunately, no treatment is still available …

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet …

M Danielewski, A Gomułkiewicz, AZ Kucharska… - International Journal of …, 2023 - mdpi.com
Atherogenesis leads to the development of atherosclerosis, a progressive chronic disease
characterized by subendothelial lipoprotein retention and endothelial impairment in the …

Borneol-Modified Schisandrin B Micelles Cross the Blood–Brain Barrier To Treat Alzheimer's Disease in Aged Mice

F Li, Y Yu, Y Du, L Kong, Y Liu, J Wang… - ACS Chemical …, 2024 - ACS Publications
Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that is
prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated that Sch …

Cornuside protects against ischemic stroke in rats by suppressing the IL-17F/TRAF6/NF-κB pathway via the brain-gut axis

C Yan, Z Liu, W Xie, T Zhang, J Zhang, G Li, X Xu… - Experimental …, 2024 - Elsevier
Ischemic stroke is a serious neurological disease with limited therapeutic options; thus, it is
particularly important to find effective treatments. Restoration of gut microflora diversity is an …

Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model

X Fei, L Wang, Y Dou, F Fei, Y Zhang, W Lv… - Journal of …, 2024 - Springer
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by
intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based …

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes

A Santiago-Balmaseda, A Aguirre-Orozco… - Cells, 2024 - mdpi.com
The astrocyte population, around 50% of human brain cells, plays a crucial role in
maintaining the overall health and functionality of the central nervous system (CNS) …

Cornus officinalis Sieb. Et Zucc. attenuates Aβ25–35-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway

B Cao, M Zeng, F Hao, Z Hao, X Liang, Z Zhang, Y Wu… - Phytomedicine, 2024 - Elsevier
Abstract Background Cornus officinalis Sieb. Et Zucc. has the efficacy of tonifying the marrow
and filling up the essence, breaking up the accumulation and opening up the orifices. Our …