Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches
In recent times, microRNA (miRNA) have emerged as primary regulators of fundamental
biological processes including cellular differentiation, proliferation, apoptosis, as well as …
biological processes including cellular differentiation, proliferation, apoptosis, as well as …
microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions
Argonaute crosslinking and immunoprecipitation (CLIP) experiments are the most widely
used high-throughput methodologies for miRNA targetome characterization. The analysis of …
used high-throughput methodologies for miRNA targetome characterization. The analysis of …
3′ LIFE: a functional assay to detect miRNA targets in high-throughput
JM Wolter, K Kotagama, AC Pierre-Bez… - Nucleic acids …, 2014 - academic.oup.com
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-
transcriptional level by targeting degenerate elements primarily in 3′ untranslated regions …
transcriptional level by targeting degenerate elements primarily in 3′ untranslated regions …
[HTML][HTML] Rules for functional microRNA targeting
D Kim, HR Chang, D Baek - BMB reports, 2017 - ncbi.nlm.nih.gov
Abstract MicroRNAs (miRNAs) are~ 22nt-long single-stranded RNA molecules that form a
RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally …
RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally …
Learning to predict miRNA-mRNA interactions from AGO CLIP sequencing and CLASH data
Recent technologies like AGO CLIP sequencing and CLASH enable direct transcriptome-
wide identification of AGO binding and miRNA target sites, but the most widely used miRNA …
wide identification of AGO binding and miRNA target sites, but the most widely used miRNA …
Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP
SA Manakov, AA Shishkin, BA Yee, KA Shen, DC Cox… - BioRxiv, 2022 - biorxiv.org
Our expanding knowledge of the roles small regulatory RNAs play across numerous areas
of biology, coupled with the promise of RNA-targeted therapies and small RNA-based …
of biology, coupled with the promise of RNA-targeted therapies and small RNA-based …
Recent computational developments on CLIP-seq data analysis and microRNA targeting implications
S Bottini, D Pratella, V Grandjean… - Briefings in …, 2018 - academic.oup.com
Abstract C ross-L inking I mmuno p recipitation associated to high-throughput seq uencing
(CLIP-seq) is a technique used to identify RNA directly bound to RNA-binding proteins …
(CLIP-seq) is a technique used to identify RNA directly bound to RNA-binding proteins …
MicroRNA target prediction using thermodynamic and sequence curves
Background MicroRNAs (miRNAs) are small regulatory RNA that mediate RNA interference
by binding to various mRNA target regions. There have been several computational …
by binding to various mRNA target regions. There have been several computational …
Divergent target recognition by coexpressed 5′-isomiRs of miR-142-3p and selective viral mimicry
Sequence heterogeneity at the ends of mature microRNAs (miRNAs) is well documented,
but its effects on miRNA function are largely unexplored. Here we studied the impact of …
but its effects on miRNA function are largely unexplored. Here we studied the impact of …
[PDF][PDF] From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data
S Bottini, N Hamouda-Tekaya, B Tanasa… - Nucleic acids …, 2017 - academic.oup.com
Experimental evidence indicates that about 60% of miRNA-binding activity does not follow
the canonical rule about the seed matching between miRNA and target mRNAs, but rather a …
the canonical rule about the seed matching between miRNA and target mRNAs, but rather a …