In this dissertation, I present two studies on miRNA regulation enabled by high-throughput
sequencing technologies and computational approaches. In the first study, we attempted to …

Much research has been directed toward understanding the roles of essential components
in the cell, such as proteins, microRNAs, and genes. This dissertation focuses on two …

The RNA revolution has turned non-coding RNA (ncRNA) from dark-matter into a biological
research hotspot. Accumulating evidence from multiple Next Generation Sequencing (NGS) …

Posttranscriptional gene regulation is important for all stages of the life of a (messenger)
RNA molecule, including splicing, nuclear/cytoplasmic export/import, transcript stability, as …

Predicting the phenotypic effects of genetic variants is a major goal in modern genetics, with
direct applicability in both the study of diseases in humans and animals, and the breeding of …

Transcription is a tightly controlled process that involves the recruitment and prost-
translational modification of DNA-associated protein complexes, which can be mapped to …

Transcription factors control numerous vital processes in the cell through their ability to
control gene expression. Dysfunctional regulation by transcription factors lead to disorders …

EBV Epstein-Barr virus HBV Hepatitis B Virus FFPE Formalin-fixed paraffin-embedded FHV
Flock horse virus HPV Human papillomavirus IIV Invertebrate iridescent virus KIMV …

The emerging technological developments during the past decade enable large scale
analyses in the “regulatory RNA” field and have turned non-coding RNA (ncRNA), initially …