Senescent cell clearance by the immune system: Emerging therapeutic opportunities
LGPL Prata, IG Ovsyannikova, T Tchkonia… - Seminars in …, 2018 - Elsevier
Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …
how and why aging turns out to be the main risk factor for the development of the most …
[HTML][HTML] Epigenetics of aging and aging-associated diseases
D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
[HTML][HTML] Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept
HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …
[HTML][HTML] Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation, and aging
SJ Wimalawansa - Biology, 2019 - mdpi.com
Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone,
has beneficial effects on several body systems other than the musculoskeletal system. Both …
has beneficial effects on several body systems other than the musculoskeletal system. Both …
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …
[HTML][HTML] Targeting immune dysfunction in aging
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …
cellular processes, with the immune system being one of the most dysregulated …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …
A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance
K Sriram, PA Insel - British journal of pharmacology, 2020 - Wiley Online Library
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …