Shorebirds and waterfowls are believed to be the reservoir hosts for influenza viruses,
whereas swine putatively act as mixing vessels. The recent identification of two influenza …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

The cap-snatching mechanism mediated by cap-dependent endonuclease, which is
common among the negative-stranded, segmented RNA viruses in Orthomyxoviridae …

The H1N1 influenza A virus, which originated in swine, caused a global pandemic in 2009,
and the highly pathogenic H5N1 avian influenza virus has also caused epidemics in …

Seasonal and pandemic influenza viruses continue to be a leading global health concern.
Emerging resistance to the current drugs and the variable efficacy of vaccines underscore …

Influenza PAN inhibitors are of particular importance in current efforts to develop a new
generation of antiviral drugs due to the growing emergence of highly pathogenic influenza …

SAMHD1 (SAM domain-and HD domain-containing protein 1) is a dGTP-dependent dNTP
triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates …

The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate
synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L …

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–
30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United …

The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It
processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for …