Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
[HTML][HTML] Macrophages at the interface of the co-evolving cancer ecosystem
DJ Kloosterman, L Akkari - Cell, 2023 - cell.com
Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …
functions in balancing immune responses and tissue repair to maintain homeostasis. This …
[HTML][HTML] Health consequences of thymus removal in adults
Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial interim results
JH Park, K Nath, SM Devlin, CS Sauter, ML Palomba… - Nature medicine, 2023 - nature.com
In preclinical models, anakinra, an IL-1 receptor antagonist (IL-1Ra), reduced immune
effector cell-associated neurotoxicity syndrome (ICANS) without compromising anti-CD19 …
effector cell-associated neurotoxicity syndrome (ICANS) without compromising anti-CD19 …
Interleukins and ischemic stroke
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …
[HTML][HTML] The role of IL-1β and TNF-α in intervertebral disc degeneration
Y Wang, M Che, J Xin, Z Zheng, J Li, S Zhang - Biomedicine & …, 2020 - Elsevier
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …
The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?
D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …
Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment
SA Ihim, SD Abubakar, Z Zian, T Sasaki… - Frontiers in …, 2022 - frontiersin.org
Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …
infections and regulates the innate and acquired immune response. IL-18 is produced by …
Cytokines in inflammatory disease
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …
Numerous studies have implicated that inflammatory cytokines exert important effects with …