Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a
common class of congenital birth defects that are associated with significant morbidity and …

About 2,000 patients now await a donor lung in the United States. Worldwide, 50 million
individuals are living with end-stage lung disease. Creation of a bioartificial lung requires …

The differentiation of alveolar epithelial type I (AT1) and type II (AT2) cells is essential for the
lung gas exchange function. Disruption of this process results in neonatal death or in severe …

Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders
continue to cause considerable neonatal and pediatric morbidity and mortality. Early …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

The lung is a unique organ in that it is exposed to physical forces derived from breathing,
blood flow, and surface tension throughout life. Over the past decade, significant progress …

Mechanical ventilation in premature infants may injure the lungs or exacerbate the pre-
existing condition that led to the need for mechanical ventilation. Ventilator-induced lung …

Mechanical forces are increasingly recognized to regulate morphogenesis, but how this is
accomplished in the context of the multiple tissue types present within a developing organ …

With increased survival of preterm infants as young as 23 weeks gestation, maintaining
adequate respiration and corresponding oxygenation represents a clinical challenge in this …