It is nearly 20 years since the concept of a small-world network was first quantitatively
defined, by a combination of high clustering and short path length; and about 10 years since …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

Technological advances in imaging techniques and biometric data acquisition have enabled
us to apply methods of network science to study the morphology and structural design of …

Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …

Emergent physical properties of tissues are not readily understood by reductionist studies of
their constituent cells. Here, we show molecular signals controlling cellular, physical, and …

Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic
and functional changes to support leukocyte migration and, in some cases, aggregation into …

Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and
stromal cells that provide ectopic hubs for acquired immune responses. TLS share …

Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in
discrete microenvironments of lymphoid organs. Despite their important role in steering …

Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …