Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …

Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …

Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

Critical-size bone defects, which require large-volume tissue reconstruction, remain a
clinical challenge. Bone engineering has the potential to provide new treatment concepts …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

Emerging spatial profiling technology has enabled high-plex molecular profiling in biological
tissues, preserving the spatial and morphological context of gene expression. Here, we …

The complexity of the blood–brain barrier (BBB) and neurovascular unit (NVU) was and still
is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the …

Microplastic (MP) pollution has become a global environmental problem, with particular
concerns for its harmful effects on human health. Several studies have demonstrated that …