[HTML][HTML] Donor-derived cell-free DNA as a diagnostic tool in transplantation

M Oellerich, K Budde, B Osmanodja… - Frontiers in …, 2022 - frontiersin.org
There is a need to improve personalized immunosuppression in organ transplantation to
reduce premature graft loss. Biomarkers are needed to better detect rejection, asymptomatic …

[HTML][HTML] How cyclosporine reduces mycophenolic acid exposure by 40% while other calcineurin inhibitors do not

T van Gelder - Kidney International, 2021 - Elsevier
The most frequently used immunosuppressive treatment in kidney transplant recipients is
the combination therapy of a calcineurin inhibitor and mycophenolate mofetil (MMF), with or …

Comparison of conventional dried blood spots and volumetric absorptive microsampling for tacrolimus and mycophenolic acid determination

L Paniagua-González, E Lendoiro… - … of Pharmaceutical and …, 2022 - Elsevier
Therapeutic drug monitoring (TDM) of immunosuppressants is essential to avoid either
rejection or toxicity after solid organ transplantations. Capillary microsampling approaches …

Volumetric microsampling for simultaneous remote immunosuppressant and kidney function monitoring in outpatient kidney transplant recipients

TC Zwart, E Metscher… - British Journal of …, 2022 - Wiley Online Library
Aims Immunosuppressant and kidney function monitoring are crucial for kidney transplant
recipient follow‐up. Microsamples enable remote sampling and minimise patient burden as …

Mycophenolic acid exposure prediction using machine learning

JB Woillard, M Labriffe, J Debord… - Clinical Pharmacology …, 2021 - Wiley Online Library
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve
(AUC) is well‐established and machine learning (ML) approaches could help to estimate …

Immune response to third SARS‐CoV‐2 vaccination in seronegative kidney transplant recipients: Possible improvement by mycophenolate mofetil reduction

M Kantauskaite, L Müller, J Hillebrandt… - Clinical …, 2022 - Wiley Online Library
Modification of vaccination strategies is necessary to improve the immune response to
SARS‐CoV‐2 vaccination in kidney transplant recipients (KTRs). This multicenter …

Therapeutic drug monitoring and dosage adjustments of immunosuppressive drugs when combined with nirmatrelvir/ritonavir in patients with COVID-19

F Lemaitre, K Budde, T Van Gelder… - Therapeutic Drug …, 2022 - journals.lww.com
Nirmatrelvir/ritonavir (Paxlovid®) consists of a peptidomimetic inhibitor (Nirmatrelvir) of the
SARS-CoV-2 main protease and a pharmacokinetic enhancer (Ritonavir). It is approved for …

[HTML][HTML] Recent advances in therapeutic drug monitoring of voriconazole, mycophenolic acid, and vancomycin: a literature review of pediatric studies

M Resztak, J Sobiak, A Czyrski - Pharmaceutics, 2021 - mdpi.com
The review includes studies dated 2011–2021 presenting the newest information on
voriconazole (VCZ), mycophenolic acid (MPA), and vancomycin (VAN) therapeutic drug …

[HTML][HTML] Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology

S Udomkarnjananun, MI Francke… - Best Practice & …, 2021 - Elsevier
Immunosuppressive drugs have been key to the success of liver transplantation and are
essential components of the treatment of inflammatory bowel disease (IBD) and autoimmune …

Volumetric Absorptive Microsampling in Therapeutic Drug Monitoring of Immunosuppressive Drugs—From Sampling and Analytical Issues to Clinical Application

A Kocur, T Pawiński - International Journal of Molecular Sciences, 2022 - mdpi.com
Miniaturisation and simplification are novel approaches in clinical bioanalysis, especially in
therapeutic drug monitoring (TDM). These contemporary trends are related to the sampling …