DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Targeting epigenetic modifications in Parkinson's disease therapy

D Zhang, J Zhang, Y Wang, G Wang… - Medicinal Research …, 2023 - Wiley Online Library
Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Development and therapeutic potential of selenazo compounds

AC Ruberte, C Sanmartin, C Aydillo… - Journal of Medicinal …, 2019 - ACS Publications
Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

Dietary nutrition for neurological disease therapy: Current status and future directions

XY Mao, XX Yin, QW Guan, QX Xia, N Yang… - Pharmacology & …, 2021 - Elsevier
Adequate food intake and relative abundance of dietary nutrients have undisputed effects on
the brain function. There is now substantial evidence that dietary nutrition aids in the …

The hyperactivity–impulsivity–irritiability–disinhibition–aggression–agitation domain in Alzheimer's disease: current management and future directions

RM Keszycki, DW Fisher, H Dong - Frontiers in pharmacology, 2019 - frontiersin.org
Behavioral and psychological symptoms of dementia (BPSD) afflict the vast majority of
patients with dementia, especially those with Alzheimer's disease (AD). In clinical settings …

Neuroepigenetics of ageing and neurodegeneration-associated dementia: an updated review

FA Mir, A Amanullah, BP Jain, Z Hyderi… - Ageing Research …, 2023 - Elsevier
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

Epigenetic biomarkers as diagnostic tools for neurodegenerative disorders

O Martínez-Iglesias, V Naidoo, N Cacabelos… - International Journal of …, 2021 - mdpi.com
Epigenetics is the study of heritable changes in gene expression that occur without
alterations to the DNA sequence, linking the genome to its surroundings. The accumulation …

DNA methylation in neurodegenerative and cerebrovascular disorders

O Martínez-Iglesias, I Carrera, JC Carril… - International journal of …, 2020 - mdpi.com
DNA methylation is an epigenetic mechanism by which methyl groups are added to DNA,
playing a crucial role in gene expression regulation. The aim of the present study is to …

Marine natural products from the Russian Pacific as sources of drugs for neurodegenerative diseases

YS Khotimchenko, DN Silachev, VL Katanaev - Marine Drugs, 2022 - mdpi.com
Neurodegenerative diseases are growing to become one of humanity's biggest health
problems, given the number of individuals affected by them. They cause enough mortalities …

Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease

Y Li, S Lin, Z Gu, L Chen, B He - Bioorganic & Medicinal Chemistry Letters, 2022 - Elsevier
Alzheimer's disease (AD) as the most prevalent dementia type has become one of the
greatest threats to the health and life of the elder people worldwide. Although there has …