Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and
progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential …

Background Genomic safe harbors are regions of the genome that can maintain transgene
expression without disrupting the function of host cells. Genomic safe harbors play an …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor
prognosis is predominantly due to the fact that most patients remain asymptomatic until the …

In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear
evidence for distorted transcriptional control as disease driver mechanisms. Defining which …

Long-range interactions between regulatory elements and promoters are key in gene
transcriptional control; however, their study requires large amounts of starting material …

The cell nucleus is a remarkably well-organized organelle with membraneless but distinct
compartments of various functions. The largest of them, euchromatin and heterochromatin …

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D
receptor (VDR) genomic actions have not been investigated in this context. We undertook …

Cancer development and progression are demarcated by transcriptional dysregulation,
which is largely attributed to aberrant chromatin architecture. Recent transformative …

Neuroinflammation and immune dysregulation play a key role in Alzheimer's disease (AD)
and are also associated with severe Covid-19 and neurological symptoms. Also, genome …

Most of the single-nucleotide polymorphisms (SNPs) associated with insulin resistance (IR)-
relevant phenotypes by genome-wide association studies (GWASs) are located in …