Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma
H Zhai, S Zhong, R Wu, Z Mo, S Zheng, J Xue… - Epigenetics, 2023 - Taylor & Francis
Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which
is closely associated with cancer progression. However, the functions and mechanisms in …
is closely associated with cancer progression. However, the functions and mechanisms in …
FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review
X Ren, X Tang, T Huang, Z Hu, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis.
Therefore, developing novel effective markers and therapeutic targets for gastrointestinal …
Therefore, developing novel effective markers and therapeutic targets for gastrointestinal …
FTO inhibits epithelial ovarian cancer progression by destabilising SNAI1 mRNA through IGF2BP2
M Sun, X Zhang, F Bi, D Wang, X Zhou, X Li, Q Yang - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the gynaecologic malignant tumour with the highest
mortality. Most patients are already in the advanced stage when they are found, and the 5 …
mortality. Most patients are already in the advanced stage when they are found, and the 5 …
A review on the role of RNA methylation in aging-related diseases
H Wei, Y Xu, L Lin, Y Li, X Zhu - International Journal of Biological …, 2024 - Elsevier
Senescence is the underlying mechanism of organism aging and is robustly regulated at the
post-transcriptional level. This regulation involves the chemical modifications, of which the …
post-transcriptional level. This regulation involves the chemical modifications, of which the …
Curcumin inhibits the invasion and migration of pancreatic cancer cells by upregulating TFPI-2 to regulate ERK-and JNK-mediated epithelial–mesenchymal transition
LL Zhai, WB Li, LJ Chen, W Wang, TF Ju… - European Journal of …, 2024 - Springer
Purpose Pancreatic cancer (PC) is one of the most deadly human malignancies. Curcumin
is a natural polyphenolic compound with wide-ranging pharmacological effects. Growing …
is a natural polyphenolic compound with wide-ranging pharmacological effects. Growing …
FTO overexpression expedites wound healing and alleviates depression in burn rats through facilitating keratinocyte migration and angiogenesis via mediating TFPI-2 …
Z Xu, X Zhu, S Mu, R Fan, B Wang, W Gao… - Molecular and Cellular …, 2024 - Springer
Burn injury is a serious traumatic injury that leads to severe physical and psychosocial
impairment. Wound healing after burn injury is a substantial challenge in medical …
impairment. Wound healing after burn injury is a substantial challenge in medical …
KCTD15 acts as an anti-tumor factor in colorectal cancer cells downstream of the demethylase FTO and the m6A reader YTHDF2
FY Zhang, L Wu, TN Zhang, HH Chen - Communications Biology, 2024 - nature.com
Abstract Potassium Channel Tetramerization Domain Containing 15 (KCTD15) participates
in the carcinogenesis of several solid malignancies; however, its role in colorectal cancer …
in the carcinogenesis of several solid malignancies; however, its role in colorectal cancer …
AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progression
P Ma, Y Hao, W Wang, YF Zhang, KH Yu, WX Wang - Discover Oncology, 2023 - Springer
Intrahepatic cholangiocarcinoma (ICC) is a fatal disease and the molecular mechanism of its
progression remains unknown. Aurora Kinase B (AURKB) is a central regulator of …
progression remains unknown. Aurora Kinase B (AURKB) is a central regulator of …
PIAS1 upregulation confers protection against Cerulein-induced acute pancreatitis via FTO downregulation by enhancing sumoylation of Foxa2
J Zhou, Q Tan, J Tong, Z Tong, C Wang, B Sun, M Fang… - Genomics, 2023 - Elsevier
Objective This research discussed the specific mechanism by which PIAS1 affects acute
pancreatitis (AP). Methods PIAS1, Foxa2, and FTO expression was assessed in Cerulein …
pancreatitis (AP). Methods PIAS1, Foxa2, and FTO expression was assessed in Cerulein …
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA
K Wang, Z Mei, M Zheng, X Liu, D Li, H Wang - Heliyon, 2024 - cell.com
The role of fat mass and obesity-associated protein (FTO), an N 6-methyladenosine (m 6 A)
demethylase, in non-small cell lung cancer (NSCLC) has recently received widespread …
demethylase, in non-small cell lung cancer (NSCLC) has recently received widespread …