In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …

Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disorder
associated with polycystic liver disease (PLD) and other extrarenal manifestations, the most …

Introduction The G protein-coupled receptors (GPCR) superfamily is among the most widely
exploited targets for therapeutics, with drugs mainly targeting the Rhodopsin, Glutamate and …

Adhesion G protein-coupled receptors (aGPCRs) comprise the second-largest class of
GPCRs, the most common target for approved pharmacological therapies. aGPCRs play an …

The adhesion family of G protein–coupled receptors (GPCRs) is defined by an N-terminal
large extracellular region that contains various adhesion-related domains and a highly …

ADGRD1 (GPR133), an adhesion G protein‐coupled receptor (GPCR), has been linked to
cancer. However, the prognostic value and regulatory function within non‐small‐cell lung …

Kidney transport and other renal functions are regulated by multiple G protein-coupled
receptors (GPCRs) expressed along the renal tubule. The rapid, recent appearance of …