Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
Philosophy of psychiatry: theoretical advances and clinical implications
DJ Stein, K Nielsen, A Hartford… - World …, 2024 - Wiley Online Library
Work at the intersection of philosophy and psychiatry has an extensive and influential
history, and has received increased attention recently, with the emergence of professional …
history, and has received increased attention recently, with the emergence of professional …
Did the human genome project affect research on Schizophrenia?
EF Torrey - Psychiatry Research, 2024 - Elsevier
Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …
and better treatments for human diseases. Schizophrenia was targeted since three of the …
Neurobiological basis of stress resilience
EJ Nestler, SJ Russo - Neuron, 2024 - cell.com
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …
function, a process referred to as resilience. Such stress resilience has been modeled in …
[HTML][HTML] Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain
Recent findings link cognitive impairment and inflammatory-immune dysregulation in
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
[HTML][HTML] Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders
C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders.
Recent findings have suggested a protective effect of the genetic liability to elevated CRP on …
Recent findings have suggested a protective effect of the genetic liability to elevated CRP on …
Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets
C Pisanu, D Congiu, A Meloni, P Paribello… - …, 2024 - nature.com
Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ)
and major depressive disorder (MDD) show a substantial reduction in life expectancy …
and major depressive disorder (MDD) show a substantial reduction in life expectancy …
Polygenic liability for antipsychotic dosage and polypharmacy-a real-world registry and biobank study
Genomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due
to limited access to large cohorts with genetic and drug prescription data. In this proof of …
to limited access to large cohorts with genetic and drug prescription data. In this proof of …
Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample
M Rejek, B Misiak - European Psychiatry, 2023 - cambridge.org
BackgroundPsychotic-like experiences (PLEs) are associated with a variety of
psychopathological symptoms. However, it remains unknown which dimensions of …
psychopathological symptoms. However, it remains unknown which dimensions of …