The success of the first licensed mRNA-based vaccines against COVID-19 has created a
widespread interest on mRNA technology for vaccinology. As expected, the number of …

In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

The unprecedented speed of delivery of SARS-CoV-2 pandemic vaccines has redefined the
limits for all vaccine development. Beyond the aspirational 100-day timeline for tomorrow's …

Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Background Plasmodium falciparum cysteine-rich protective antigen (Pf CyRPA) is an
invasion complex protein essential for erythrocyte invasion. In contrast to several previously …

Preferred product characteristics”(PPCs) are key tools to incentivize and guide the
development of urgently needed health products. The PPCs published here aim to articulate …

Malaria sterile immunity has been reproducibly induced by immunization with Plasmodium
radiation-attenuated sporozoites (RAS). Analyses of sera from RAS-immunized individuals …

Malaria remains a relevant global health problem. In 2021, the WHO estimated 247 million
cases worldwide, which led to more than 600,000 deaths, mainly due to severe malaria …

Controlled human infection studies have contributed significantly to the understanding of
pathogeneses and treatment of infectious diseases. In malaria, deliberately infecting …

Background Malaria is preventable yet causes> 600 000 deaths annually. RTS, S, the first
marketed malaria vaccine, has modest efficacy, but improvements are needed for …