Interferon (IFN) represents a well-known component of antiviral immunity that has been
studied extensively for its mechanisms of action and therapeutic potential when antiviral …

Adult-onset immunodeficiency syndrome due to anti-interferon (IFN)-γ autoantibodies has
attracted much attention in recent years. It usually occurs in previously healthy people and …

Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

Interferons control viral infection by inducing the expression of antiviral effector proteins
encoded by interferon‐stimulated genes (ISGs). The field has mostly focused on identifying …

SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from
asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals …

Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also
modulate immune responses by acting through a heterodimeric receptor composed of the …

Interferons play a critical role in the innate immune response against several infections and
play a key role in the control of a variety of viral and bacterial infectious diseases such as …

Background The clinical course of COVID-19 patients ranges from asymptomatic infection,
via mild and moderate illness, to severe disease and even fatal outcome. Biomarkers which …

In this study, we developed a novel, multiplex qPCR assay for simultaneous detection of RIG-
1, MDA5, and IFIT-1 at the mRNA level. The assay was validated in A549 cells transfected …

Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-
6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in …