[HTML][HTML] Diabetic keratopathy: redox signaling pathways and therapeutic prospects

F Buonfiglio, J Wasielica-Poslednik, N Pfeiffer… - Antioxidants, 2024 - mdpi.com
Diabetes mellitus, the most prevalent endocrine disorder, not only impacts the retina but also
significantly involves the ocular surface. Diabetes contributes to the development of dry eye …

[HTML][HTML] Redox mechanisms in autoimmune thyroid eye disease

F Buonfiglio, KA Ponto, N Pfeiffer, GJ Kahaly… - Autoimmunity …, 2024 - Elsevier
Thyroid eye disease (TED) is an autoimmune condition affecting the orbit and the eye with
its adnexa, often occurring as an extrathyroidal complication of Graves' disease (GD). Orbital …

Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency

V Nithianandam, S Sarkar… - Human Molecular …, 2024 - academic.oup.com
Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are
common, severe and untreatable. We recovered a number of mitochondrial genes, including …

Type I Collagen‐Adhesive and ROS‐Scavenging Nanoreactors Enhanced Retinal Ganglion Cell Survival in an Experimental Optic Nerve Crush Model

Y Du, M Cai, J Mu, X Li, Y Song, X Yuan… - Macromolecular …, 2023 - Wiley Online Library
Traumatic optic neuropathy (TON) is a severe condition characterized by retinal ganglion
cell (RGC) death, often leading to irreversible vision loss, and the death of RGCs is closely …

[PDF][PDF] Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System

F Buonfiglio, CA Korb, B Stoffelns, N Pfeiffer… - Aging Dis., 2024 - researchgate.net
Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central
retina, which holds global significance as the fourth leading cause of blindness. The …

[HTML][HTML] Retinopathy of Prematurity—Targeting Hypoxic and Redox Signaling Pathways

L Zhang, F Buonfiglio, A Fieß, N Pfeiffer, A Gericke - Antioxidants, 2024 - mdpi.com
Retinopathy of prematurity (ROP) is a proliferative vascular ailment affecting the retina. It is
the main risk factor for visual impairment and blindness in infants and young children …

[HTML][HTML] Diabetic Retinopathy: New Treatment Approaches Targeting Redox and Immune Mechanisms

Q Tang, F Buonfiglio, EW Böhm, L Zhang, N Pfeiffer… - Antioxidants, 2024 - mdpi.com
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus,
characterized by irreversible visual impairment resulting from microvascular abnormalities …

[HTML][HTML] Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress

X Cui, F Buonfiglio, N Pfeiffer, A Gericke - Biomedicines, 2024 - mdpi.com
Acknowledged as a significant pathogenetic driver for numerous diseases, aging has
become a focal point in addressing the profound changes associated with increasing human …

[HTML][HTML] Orbital Inflammation in Thyroid Eye Disease: Stress Responses and Their Implications

T Aoun, D Danielova Gueorguieva, KY Wu - Stresses, 2024 - mdpi.com
Thyroid Eye Disease (TED) is a debilitating autoimmune condition characterized by
significant inflammation of orbital tissues, including the extraocular muscles and adipose …

[HTML][HTML] The Effect of Trabecular Aspiration on Intraocular Pressure, Medication and the Need for Further Glaucoma Surgery in Eyes with Pseudoexfoliation Glaucoma

V Prokosch, SB Zwingelberg, DV Efremova… - Diseases, 2024 - mdpi.com
Purpose: To investigate whether trabecular aspiration (TA) has an effective medium-term
intraocular pressure (IOP)-lowering and medication-saving effect in patients with …