Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …

Owing to a dramatic increase in average life expectancy and the Family Planning program of
the 1970s-1990s, China is rapidly becoming an aging society. Therefore, the investigation of …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …