Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota
through fermentation of dietary fiber. SCFAs participate a number of physiological and …

Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …

Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …

Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main
precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which …

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …

Chromatin and metabolic states both influence lifespan, but how they interact in lifespan
regulation is largely unknown. The COMPASS chromatin complex, which trimethylates …