Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Y Ma, G Lee, SY Heo, YS Roh - Antioxidants, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

d-amino Acids in Health and Disease: A Focus on Cancer

JJAJ Bastings, HM van Eijk, SW Olde Damink… - Nutrients, 2019 - mdpi.com
d-amino acids, the enantiomeric counterparts of l-amino acids, were long considered to be
non-functional or not even present in living organisms. Nowadays, d-amino acids are …

MicroRNA and ROS crosstalk in cardiac and pulmonary diseases

M Climent, G Viggiani, YW Chen, G Coulis… - International Journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Human D-amino acid oxidase: structure, function, and regulation

L Pollegioni, S Sacchi, G Murtas - Frontiers in Molecular Biosciences, 2018 - frontiersin.org
D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …

A guide to genetically encoded tools for the study of H2O2

DD Smolyarova, OV Podgorny, DS Bilan… - The FEBS …, 2022 - Wiley Online Library
Cell metabolism heavily relies on the redox reactions that inevitably generate reactive
oxygen species (ROS). It is now well established that ROS fluctuations near basal levels …

Enantiomer-dependent supramolecular immunosuppressive modulation for tissue reconstruction

Z Mu, T Shen, H Deng, B Zeng, C Huang, Z Mao… - ACS …, 2024 - ACS Publications
Modulating the properties of biomaterials in terms of the host immune response is critical for
tissue repair and regeneration. However, it is unclear how the preference for the cellular …

Directly and indirectly targeting the glycine modulatory site to modulate NMDA receptor function to address unmet medical needs of patients with schizophrenia

JC Pei, DZ Luo, SS Gau, CY Chang, WS Lai - Frontiers in Psychiatry, 2021 - frontiersin.org
Schizophrenia is a severe mental illness that affects~ 1% of the world's population. It is
clinically characterized by positive, negative, and cognitive symptoms. Currently available …

Raising the 'good'oxidants for immune protection

A Dumas, UG Knaus - Frontiers in immunology, 2021 - frontiersin.org
Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and
secondary reaction products for health benefit. The concomitant function of ROS as …

Modulation of microglia by voluntary exercise or CSF1R inhibition prevents age-related loss of functional motor units

E Giorgetti, M Panesar, Y Zhang, S Joller, M Ronco… - Cell reports, 2019 - cell.com
Age-related loss of skeletal muscle innervation by motor neurons leads to impaired
neuromuscular function and is a well-established clinical phenomenon. However, the …

Peroxisomal dysfunction in neurodegenerative diseases

DS Jo, DH Cho - Archives of pharmacal research, 2019 - Springer
Peroxisomes and their (patho-) physiological importance in heath and disease have
attracted increasing interest during last few decades. Together with mitochondria …