[HTML][HTML] Urinary tract infections: the current scenario and future prospects

G Mancuso, A Midiri, E Gerace, M Marra, S Zummo… - Pathogens, 2023 - mdpi.com
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide,
occurring in both community and healthcare settings. Although the clinical symptoms of UTIs …

[HTML][HTML] Evaluation of antibiotic resistance mechanisms in gram-negative bacteria

A Gauba, KM Rahman - Antibiotics, 2023 - mdpi.com
Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing
one of the most urgent global healthcare and economic threats. Due to the lack of new …

[HTML][HTML] Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

B Van Nieuwenhuyse, D Van der Linden… - Nature …, 2022 - nature.com
Post-operative bacterial infections are a leading cause of mortality and morbidity after
ongoing liver transplantation. Bacteria causing these infections in the hospital setting can …

Silver─ Gallium nano‐amalgamated particles as a novel, biocompatible solution for antibacterial coatings

TT Nguyen, P Zhang, J Bi, NH Nguyen… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial infections account for countless deaths globally. Antibiotics are the primary
countermeasure; however, the alarming spread of antibiotic‐resistant strains necessitates …

[HTML][HTML] EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

M Pinilla, R Mazars, R Vergé, L Gorse… - The Journal of …, 2023 - ncbi.nlm.nih.gov
Human airway and corneal epithelial cells, which are critically altered during chronic
infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome …

[HTML][HTML] An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa

CJ Harding, M Bischoff, M Bergkessel… - Nature Chemical …, 2023 - nature.com
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness,
especially in immunocompromised individuals. P. aeruginosa forms biofilms that contribute …

[HTML][HTML] Combination of genetically diverse Pseudomonas phages enhances the cocktail efficiency against bacteria

A Naknaen, T Samernate, W Wannasrichan… - Scientific Reports, 2023 - nature.com
Phage treatment has been used as an alternative to antibiotics since the early 1900s.
However, bacteria may acquire phage resistance quickly, limiting the use of phage …

Natural and synthetic molecules with potential to enhance biofilm formation and virulence properties in Pseudomonas aeruginosa

GJ Jeong, F Khan, N Tabassum… - Critical Reviews in …, 2023 - Taylor & Francis
Pseudomonas aeruginosa can efficiently adapt to changing environmental conditions due to
its ubiquitous nature, intrinsic/acquired/adaptive resistance mechanisms, high metabolic …

[HTML][HTML] Relationship between Biofilm-Formation, Phenotypic Virulence Factors and Antibiotic Resistance in Environmental Pseudomonas aeruginosa

P Behzadi, M Gajdács, P Pallós, B Ónodi, A Stájer… - Pathogens, 2022 - mdpi.com
The formation of a protective biofilm by Pseudomonas aeruginosa (PA) is one of the
hallmarks of their survival both in vivo and in harsh environmental conditions, thus, biofilm …

[HTML][HTML] Antibiotic resistance in patients with cystic fibrosis: past, present, and future

EP Perikleous, D Gkentzi, A Bertzouanis, E Paraskakis… - Antibiotics, 2023 - mdpi.com
Patients with cystic fibrosis (CF) are repeatedly exposed to antibiotics, especially during the
pulmonary exacerbations of the disease. However, the available therapeutic strategies are …