Mitochondrial quality control: a pathophysiological mechanism and therapeutic target for stroke

M Yang, Y He, S Deng, L Xiao, M Tian, Y Xin… - Frontiers in Molecular …, 2022 - frontiersin.org
Stroke is a devastating disease with high mortality and disability rates. Previous research
has established that mitochondria, as major regulators, are both influenced by stroke, and …

Glial cells: an important switch for the vascular function of the central nervous system

L Gao, X Pan, JH Zhang, Y Xia - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
In this review, we first describe the current understanding of glial-mediated vascular function
affecting the role of the blood-brain barrier (BBB) in central nervous system (CNS) disorders …

Caveolin-1 aggravates neurological deficits by activating neuroinflammation following experimental intracerebral hemorrhage in rats

D Cao, B Li, C Cao, J Zhang, X Li, H Li, Z Yu… - Experimental …, 2023 - Elsevier
Background Intracerebral hemorrhage (ICH) is one of the stroke subtypes with the highest
mortality. Secondary brain injury is associated with neurological dysfunction and poor …

Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures

E Rowsthorn, W Pham, MR Nazem-Zadeh… - Fluids and Barriers of …, 2023 - Springer
The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and
metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid …

The Improvement of Sepsis‐Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

K Wang, M Sun, Z Juan, J Zhang, Y Sun… - Behavioural …, 2022 - Wiley Online Library
The pathogenesis of sepsis‐associated encephalopathy (SAE) involves many aspects,
including intracellular peroxidative stress damage, mitochondrial dysfunction, and cell …

Neuroprotection by ozanimod following intracerebral hemorrhage in mice

F Wang, X Zhang, Y Liu, Z Li, R Wei… - Frontiers in Molecular …, 2022 - frontiersin.org
The destruction of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) is
associated with poor prognosis. Modulation of sphingosine 1-phosphate receptor (S1PR) …

Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier …

L Gao, L Peng, P Sherchan, H Tang, Y Liu… - Fluids and Barriers of …, 2023 - Springer
Backgroud The frequencies of morbidity and impairment associated with spontaneous
intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity …

Mechanism of spontaneous intracerebral hemorrhage formation: an anatomical specimens-based study

R Rzepliński, M Sługocki, S Tarka, M Tomaszewski… - Stroke, 2022 - Am Heart Assoc
Background: Despite advances in understanding various risk and prognostic factors,
spontaneous intracerebral hemorrhage is connected to very high morbidity and mortality …

From static to dynamic: live observation of the support system after ischemic stroke by two photon-excited fluorescence laser-scanning microscopy

X Wu, JR Li, Y Fu, DY Chen, H Nie… - Neural Regeneration …, 2023 - journals.lww.com
Ischemic stroke is one of the most common causes of mortality and disability worldwide.
However, treatment efficacy and the progress of research remain unsatisfactory. As the …

Activation of LRP6 with HLY78 Attenuates Oxidative Stress and Neuronal Apoptosis via GSK3β/Sirt1/PGC‐1α Pathway after ICH

P Jin, D Qi, Y Cui, C Lenahan… - Oxidative Medicine and …, 2022 - Wiley Online Library
Background. Oxidative stress and neuronal apoptosis have important roles in the
pathogenesis after intracerebral hemorrhage (ICH). Previous studies have reported that low …