Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

RNA-based diagnostic markers discovery and therapeutic targets development in cancer

H Wang, Q Meng, J Qian, M Li, C Gu, Y Yang - Pharmacology & …, 2022 - Elsevier
The present review aimed to outline different types of RNAs in cancer diagnostics and
treatment, and to provide novel insights into their clinical applications. RNAs, including …

Emerging roles of non-coding RNA transcription

MU Kaikkonen, K Adelman - Trends in biochemical sciences, 2018 - cell.com
Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly
few of these RNAs encode proteins. Accordingly, there is great interest in understanding the …

LncFinder: an integrated platform for long non-coding RNA identification utilizing sequence intrinsic composition, structural information and physicochemical property

S Han, Y Liang, Q Ma, Y Xu, Y Zhang… - Briefings in …, 2019 - academic.oup.com
Discovering new long non-coding RNAs (lncRNAs) has been a fundamental step in lncRNA-
related research. Nowadays, many machine learning-based tools have been developed for …

The role of M6A modification in the regulation of tumor-related lncRNAs

Y Lan, B Liu, H Guo - Molecular Therapy-Nucleic Acids, 2021 - cell.com
N 6-methyladenosine (m 6 A) is the most abundant modification in eukaryotic cells, and it
regulates RNA transcription, processing, splicing, degradation, and translation. Long non …

Update on the genetics of keratoconus

Y Bykhovskaya, YS Rabinowitz - Experimental Eye Research, 2021 - Elsevier
In the past few years we have seen a great acceleration of discoveries in the field of
keratoconus including new treatments, diagnostic tools, genomic and molecular …

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels… - Genome biology, 2017 - Springer
Background Whole-exome sequencing (WES) has been successful in identifying genes that
cause familial Parkinson's disease (PD). However, until now this approach has not been …

lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA

F Seifuddin, K Singh, A Suresh, JT Judy, YC Chen… - Scientific Data, 2020 - nature.com
Long non-coding RNA Knowledgebase (lncRNAKB) is an integrated resource for exploring
lncRNA biology in the context of tissue-specificity and disease association. A systematic …

Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities

E Loukovitis, K Sfakianakis, P Syrmakesi… - Ophthalmology and …, 2018 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting …

H Zhang, S Liu, L Tang, J Ge, X Lu - Bioengineered, 2021 - Taylor & Francis
Long non-coding RNA (LncRNA) contributes to the occurrence and development of
osteosarcoma (OS), although the underlying mechanism is not clear. In the present study …