ABSTRACT Purpose CYP3A4 and P-glycoprotein (P-gp) are present in the human intestine
and mediate intestinal first-pass metabolism and the efflux of oral drugs, respectively. We …

Drug–drug interactions (DDIs) related to altered drug absorption and plasma protein binding
have received much less attention from regulatory agencies relative to DDIs mediated via …

Purpose To evaluate vinorelbine drug exposure and activity in brain metastases of the
human MDA-MB-231BR breast cancer model using integrated imaging and analysis …

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal
absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated …

We report development and prospective validation of a QSAR model of the unbound brain-to-
plasma partition coefficient, K p, uu, brain, based on the in-house data set of∼ 1000 …

A simple, sensitive and specific reversed phase high performance liquid chromatographic
(RP-HPLC) method with UV detection at 251nm was developed for simultaneous …

Pleckstrin homology domain and leucine rich repeat protein phosphatase (PHLPP) knockout
mice have improved outcomes after a stroke, traumatic brain injury (TBI), and decreased …

This chapter summarizes the significance of suspension in preclinical development. Majority
of the preclinical studies are carried out using suspension. Therefore, it is important to know …

The vast majority of marketed drugs are orally administrated. As such, drug absorption is
one of the important drug metabolism and pharmacokinetics parameters that should be …

Pharmacokinetics is the study of how the body causes changes in drugs, and includes
analysis of absorption, distribution, metabolism and excretion. It is essential to understand …