This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …

Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells
and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in …

Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR)
against human carcinoembryonic antigen (CEA) were administered to three patients with …

Abstract Since September 11, 2001, there has been the recognition of a plausible threat
from acts of terrorism, including radiological or nuclear attacks. A network of Centers for …

Cancer immunotherapeutic approaches induce tumor-specific immune responses, in
particular CTL responses, in many patients treated. However, such approaches are clinically …

Immune homeostasis is a delicate balance between the immune defense against foreign
pathogens and suppression of the immune system to maintain self-tolerance and prevent …

Immune cell infiltration in the tumor microenvironment is of prognostic and therapeutic
import. These immune cell subsets can be heterogeneous and are composed of mature …

Toll-like receptors (TLRs) are pattern-recognition receptors related to the Drosophila Toll
protein. TLR activation alerts the immune system to microbial products and initiates innate …

Lymphodepletion before adoptive cell transfer (ACT)-based immunotherapies can enhance
anti-tumor responses by augmenting innate immunity, by increasing access to homeostatic …

Toll-like receptors (TLR) expressed on inflammatory cells play a key role in host defense
against pathogens, benefiting the host. TLR are also expressed on tumor cells. To evaluate …