For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger
sequential and complex metabolic and cellular pathologies. This leads to brain tissue …

Dynamic changes in circulating and tissue metabolites and lipids occur in response to
exercise-induced cellular and whole-body energy demands to maintain metabolic …

Background: For thousands of years, disabilities due to nutrient deficiencies have plagued
humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps due to …

Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Aim Brain microvascular endothelial cells (BMVECs), as the important structure of blood-
brain barrier (BBB), play a vital role in ischemic stroke. Pyroptosis of different cells in the …

Existing techniques have many limitations in the diagnosis and classification of ischemic
stroke (IS). Considering this, we used metabolomics to screen for potential biomarkers of IS …

Background: To discover novel metabolic biomarkers of ischemic stroke (IS), we carried out
a two-stage metabolomic profiling of IS patients and healthy controls using untargeted and …

Background In recent years, studies have shown that exposure to environmental pollutants
(eg, radiation, heavy metal substances, air pollutants, organic pollutants) is a leading cause …