The prevalence of neutral mutations in cancer cell population impedes the distinguishing of
cancer-causing driver mutations from passenger mutations. To systematically prioritize the …

Microtia epigenetics: An overview of review and new viewpoin... : Medicine Microtia
epigenetics: An overview of review and new viewpoint : Medicine Log in or Register Get …

Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells
are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 …

Optimal methods could effectively improve the accuracy of predicting and identifying
candidate driver genes. Various computational methods based on mutational frequency …

De novo mutations (DNMs) significantly contribute to sporadic diseases, particularly in
neuropsychiatric disorders. Whole-exome sequencing (WES) and whole-genome …

Rapid advances in high-throughput sequencing technologies have led to the discovery of
thousands of extrachromosomal circular DNAs (eccDNAs) in the human genome. Loss-of …

Whole-exome and whole-genome sequencing have revealed millions of somatic mutations
associated with different human cancers, and the vast majority of them are located outside of …

The novel coronavirus SARS-CoV-2 is damaging the world's social and economic fabrics
seriously. Effective drugs are urgently needed to decrease the high mortality rate of COVID …

The current challenge in cancer research is to increase the resolution of driver prediction
from gene-level to mutation-level, which is more closely aligned with the goal of precision …

Somatic synonymous mutations are one of the most frequent genetic variants occurring in
the coding region of cancer genomes, while their contributions to cancer development …