Type 2 diabetes

E Ahmad, S Lim, R Lamptey, DR Webb, MJ Davies - The Lancet, 2022 - thelancet.com
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes
worldwide. The number affected is increasing rapidly with alarming trends in children and …

Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

[HTML][HTML] Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients
admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods …

[HTML][HTML] Psychiatric and neuropsychiatric sequelae of COVID-19–A systematic review

TM Schou, S Joca, G Wegener… - Brain, behavior, and …, 2021 - Elsevier
It has become evident that coronavirus disease 2019 (COVID-19) has a multi-organ
pathology that includes the brain and nervous system. Several studies have also reported …

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

[PDF][PDF] Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort in Wuhan, China

L Liu, HG Chen, Y Li, H Li, J Li… - Eng …, 2021 - devp-service.oss-cn-beijing.aliyuncs …
abstract The longitudinal immunologic status of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)-infected patients and its association with the clinical outcome …

Cytokines: from clinical significance to quantification

C Liu, D Chu, K Kalantar‐Zadeh, J George… - Advanced …, 2021 - Wiley Online Library
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …

Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

L Montefusco, M Ben Nasr, F D'Addio, C Loretelli… - Nature …, 2021 - nature.com
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …