ABSTRACT A major advantage of DNA vaccination is the ability to induce both humoral and
cellular immune responses. DNA vaccines are currently used in veterinary medicine, but …

T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …

IL-15 is normally presented in vivo as a cell-associated cytokine bound to IL-15Rα. We show
here that the biological activity of soluble IL-15 is much improved after interaction with …

IL-15 has substantial potential as an immunotherapeutic agent for augmenting immune
responses. However, the activity of IL-15 is mediated by a unique mechanism in which the …

The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL …

The high affinity interleukin (IL)-15 receptor, IL-15Rα, is essential for supporting lymphoid
homeostasis. To assess whether IL-15Rα's role in vivo is to trans present IL-15, we …

Abstract Type I IFN (IFN-αβ), which is produced rapidly in response to infection, plays a key
role in innate immunity and also acts as a stimulus for the adaptive immune response. We …

Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to
their high expression level of peptide‐MHC and an array of accessory molecules involved in …

The characteristics, importance, and molecular requirements for interactions between mast
cells (MCs) and CD8+ T cells have not been elucidated. Here, we demonstrated that MCs …

We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor α (IL-15Rα) in the
same cell allows for the intracellular interaction of the two proteins early after translation …