Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the
function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar …

Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …

Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …

Several lines of evidence have suggested for decades a role for norepinephrine (NE) in the
pathophysiology and treatment of schizophrenia. Recent experimental findings reveal …

Background The effects of ambient air pollution on specific mental disorders are rarely
studied, and the reported results are inconsistent. Objective To assess the short-term effect …

At present, current diagnostic criteria and systems neglect affective symptom expression in
catatonia. This potentially serious omission could explain why putative contributions of …