[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

[HTML][HTML] The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

[HTML][HTML] Neuroinflammation as the underlying mechanism of postoperative cognitive dysfunction and therapeutic strategies

Z Li, Y Zhu, Y Kang, S Qin, J Chai - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication following
surgery/general anesthesia, especially in elderly patients. Severe cases will greatly delay …

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

LL Qiu, W Pan, D Luo, GF Zhang, ZQ Zhou… - Journal of …, 2020 - Springer
Background Postoperative cognitive decline (POCD) is a recognized clinical phenomenon
characterized by cognitive impairments in patients following anesthesia and surgery, yet its …

Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning

IB Hovens, RG Schoemaker, EA van der Zee… - Brain, behavior, and …, 2014 - Elsevier
Postoperative cognitive dysfunction (POCD) has been hypothesized to be mediated by
surgery-induced inflammatory processes, which may influence neuronal functioning either …

[HTML][HTML] Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF

S Mitra, H Behbahani, M Eriksdotter - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …

Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction

X Tan, LL Qiu, J Sun - BioMed research international, 2021 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio

I Hovens, C Nyakas, R Schoemaker - Neuroimmunology and …, 2014 - research.rug.nl
Aim: The aim was to validate a newly developed methodology of semi-automatic image
analysis to analyze microglial morphology as marker for microglial activation in ionized …

Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders

C Cheng, H Wan, P Cong, X Huang, T Wu… - Journal of …, 2022 - Springer
Perioperative neurocognitive disorders (PND) is a common postoperative complication
associated with regional or general anesthesia and surgery. Growing evidence in both …

Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral injury …

Y Qiao, H Feng, T Zhao, H Yan, H Zhang, X Zhao - BMC anesthesiology, 2015 - Springer
Background Elderly patients are reportedly at higher risk of postoperative cognitive
dysfunction (POCD) after inhalational anesthesia with sevoflurane. We hypothesized that the …