Objectives To compare the deposition patterns within the nasal cavity between the bi‐
directional and unilateral nasal delivery systems. And to summarize the clinical application …

Direct nose-to-brain drug delivery offers the opportunity to treat central nervous system
disorders more effectively due to the possibility of drug molecules reaching the brain without …

Alzheimer's disease (AD) is a neurodegenerative disorder that progressively compromises
cognitive functions. Tumor necrosis factor (TNF)-Related Apoptosis Inducing Ligand …

Objectives Nanotechnology-based nasal delivery systems have gained interest as a way of
overcoming low drug bioavailability, limited brain exposure, fast metabolism and elimination …

The demand for a more efficient and targeted method for intranasal drug delivery has led to
sophisticated device design, delivery methods, and aerosol properties. Due to the complex …

Identifying the deposition pattern of inhaled pharmaceutical aerosols in the human
respiratory system and understanding the effective parameters in this process is vital for …

The nasal epithelium is an important target for drug delivery to the nose and secondary
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …

Although pulmonary drug delivery has been deeply investigated, the effect of the laryngeal
jet on particle deposition during drug delivery with dry powder inhalers (DPI) has not been …

Administering aerosol drugs through the nasal pathway is a common early treatment for
children with adenoid hypertrophy (AH). To enhance therapeutic efficacy, a deeper …

Nasal administration can be used to treat not only local and systemic diseases but also
central nervous system diseases. However, the delivery efficiency to the target site needs to …