There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Cellular lipid membranes serve as the primary barrier preventing viral infection of the host
cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein AI, A-II,
and B levels while triglyceride levels may be increased or inappropriately normal for the …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces low density lipoprotein (LDL)
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …

Background Many commonly used drugs were evaluated as repurposed treatment options
since the emergence of the COVID-19 pandemic. The benefit of lipid-lowering agents has …

Epidemiologic registry data show that the incidence of myocardial infarction is increased in
SARS-CoV-2-infected HeFH patients. There is a need to study whether the risk for acute …

Cardiovascular diseases (CVDs) are the leading cause of death among elderly people.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator of …

Statins may protect against adverse outcomes from Coronavirus disease 2019 (COVID‐19)
through their pleiotropic effects. Endothelial dysfunction seems to be implicated in the …

Proprotein convertases activate various envelope glycoproteins and participate in cellular
entry of many viruses. We recently showed that the convertase furin is critical for the …