The cytochrome P450 enzymes (CYPs), a group of heme-containing enzymes, catalyze
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …

Introduction Physiologically based pharmacokinetics (PBPK) models are increasingly used
in the drug research and development, especially in anti-cancer drugs. Between 2001 and …

Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among
immunocompromised patients with underlying malignancies and prior transplants. FDA …

The magnitude of drug-drug interaction between tacrolimus and voriconazole is highly
variable, and individually tailoring the tacrolimus dose when concomitantly administered …

Introduction Deglycosylated azithromycin (Deg-AZM), a newly developed Class I drug with
good therapeutic effects on slow transit constipation, is a small-molecule transgelin agonist …

Abstract Background and Objective Voriconazole (VRC), a broad-spectrum antifungal drug,
exhibits nonlinear pharmacokinetics (PK) due to saturable metabolic processes …

Coronavirus disease 2019 (COVID‐19)‐associated pulmonary aspergillosis superinfection
with cytokine storm is associated with increased mortality. This study aimed to establish a …

Tacrolimus is the principal immunosuppressive drug which is administered after heart
transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic …

Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a
variety of solid tumors. This study aims to investigate the potential pharmacokinetic …

This article describes a potential treatment for early T-cell precursor acute lymphoblastic
leukemia (ETP-ALL), a relatively rare and highly aggressive hematologic malignancy. A 59 …