Transdiagnostic behavioral and genetic contributors to repetitive negative thinking: a machine learning approach

KL Forthman, R Kuplicki, H Yeh, SS Khalsa… - Journal of psychiatric …, 2023 - Elsevier
Background Repetitive negative thinking (RNT) is a symptom that can negatively impact the
treatment and course of common psychiatric disorders such as depression and anxiety. We …

Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans

NA Kimbrel, ME Garrett, MK Evans, C Mellows… - Frontiers in …, 2023 - frontiersin.org
Introduction The US suicide mortality rate has steadily increased during the past two
decades, particularly among military veterans; however, the epigenetic basis of suicidal …

Neurodevelopmental disorders and suicide: a narrative review

A Gagliano, C Costanza, I Di Modica, S Carucci… - Journal of clinical …, 2024 - mdpi.com
Specific risk factors for self-harm and suicide in children and adolescents with
neurodevelopmental disorders (NDD) may differ from those in the general population within …

Genetic signatures of suicide attempt behavior: insights and applications

A Drago - Expert review of proteomics, 2024 - Taylor & Francis
Introduction Every year about 800,000 complete suicide events occur. The identification of
biologic markers to identify subjects at risk would be helpful in targeting specific support …

Identification of novel targets and pathways to distinguish suicide dependent or independent on depression diagnosis

S Peng, Y Zhou, L Xiong, Q Wang - Scientific reports, 2023 - nature.com
In recent years, postmortem brain studies have revealed that some molecular, cellular, and
circuit changes associated with suicide, have an independent or additive effect on …

Brain and blood transcriptome profiles delineate common genetic pathways across suicidal ideation and suicide

S Sun, Q Liu, Z Wang, Y Huang, ME Sublette… - Molecular …, 2024 - nature.com
Human genetic studies indicate that suicidal ideation and behavior are both heritable. Most
studies have examined associations between aberrant gene expression and suicide …

Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes

S Han, E DiBlasi, ET Monson, A Shabalin, E Ferris… - Molecular …, 2023 - nature.com
Recent large-scale genome-wide association studies (GWAS) have started to identify
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …

New insights into suicidal behavior from large multi-ancestry genetic meta-analysis

EB Binder - American journal of psychiatry, 2023 - Am Psychiatric Assoc
Suicide is the second leading cause of death among 15-to 29-year-olds (1), and a history of
psychiatric disorders is one of the main risk factors. Hence, understanding the causes of and …

Genetic factors associated with suicidal behaviors and alcohol use disorders in an American Indian population

Q Peng, DA Gilder, RA Bernert, KJ Karriker-Jaffe… - Molecular …, 2024 - nature.com
American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and
alcohol use disorders (AUD) among all ethnic groups in the US. Rates of suicide and AUD …

Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

H Ohseto, I Takahashi, A Narita, T Obara… - Depression and …, 2024 - Wiley Online Library
This study is aimed at revealing the risk factors, prognosis, influence on offspring, and
genetic architecture of perinatal depression (PD) classified based on the depressive …