Substitution models of protein evolution with selection on enzymatic activity
Substitution models of evolution are necessary for diverse evolutionary analyses including
phylogenetic tree and ancestral sequence reconstructions. At the protein level, empirical …
phylogenetic tree and ancestral sequence reconstructions. At the protein level, empirical …
Selection among site-dependent structurally constrained substitution models of protein evolution by approximate Bayesian computation
Motivation The selection among substitution models of molecular evolution is fundamental
for obtaining accurate phylogenetic inferences. At the protein level, evolutionary analyses …
for obtaining accurate phylogenetic inferences. At the protein level, evolutionary analyses …
Multi-conformation Aproach of ENM-NMA Dynamic-Based Descriptors for HIV Drug Resistance Prediction
JA Jimenez-Gari, M Pupo-Meriño, HR Gonzalez… - … Congress on Pattern …, 2023 - Springer
Drug resistance is a key factor in the failure of drug therapy, as the antiretroviral therapy
against the human immunodeficiency virus (HIV). Due to the high costs of direct phenotypic …
against the human immunodeficiency virus (HIV). Due to the high costs of direct phenotypic …