Schizophrenia is increasingly recognized as a systemic disease, characterized by
dysregulation in multiple physiological systems (eg, neural, cardiovascular, endocrine) …

Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …

Pneumonia remains one of the leading causes of death worldwide. In this study, we use
genome-wide meta-analysis of lifetime pneumonia diagnosis (N= 391,044) to identify four …

Psychiatric disorders such as schizophrenia are commonly associated with structural brain
alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites …

Background Metabolic disturbance has been reported in patients with epilepsy. Still, the
evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking …

Genetically informed drug development and repurposing is an attractive prospect for
improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Background Many observational epidemiology studies discovered that kidney cancer and
impaired kidney function have a bidirectional relationship. However, it remains unclear …

We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Cannabis use disorder (CUD) remains a significant public health issue globally, affecting up
to one in five adults who use cannabis. Despite extensive research into the molecular …