Mitophagy in human diseases

L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

The role of glutamate receptors in epilepsy

TS Chen, TH Huang, MC Lai, CW Huang - Biomedicines, 2023 - mdpi.com
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy

ALM Parsons, EMV Bucknor, E Castroflorio, TR Soares… - Antioxidants, 2022 - mdpi.com
One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

[HTML][HTML] The solute carrier transporters and the brain: Physiological and pharmacological implications

C Hu, L Tao, X Cao, L Chen - Asian journal of pharmaceutical sciences, 2020 - Elsevier
Solute carriers (SLCs) are the largest family of transmembrane transporters that determine
the exchange of various substances, including nutrients, ions, metabolites, and drugs across …

Glial glutamine homeostasis in health and disease

JV Andersen, A Schousboe - Neurochemical Research, 2023 - Springer
Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Microglia in neuroimmunopharmacology and drug addiction

H Li, LR Watkins, X Wang - Molecular Psychiatry, 2024 - nature.com
Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Chimeric antigen receptor T cell-related neurotoxicity: mechanisms, clinical presentation, and approach to treatment

J Rice, S Nagle, J Randall, HE Hinson - Current treatment options in …, 2019 - Springer
Purpose of review Chimeric antigen receptor T cell (CAR-T) adoptive cell therapy is an
effective treatment for patients with refractory B cell malignancies. As its use has grown …

Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

A Plata, A Lebedeva, P Denisov, O Nosova… - Frontiers in molecular …, 2018 - frontiersin.org
Epilepsy is a group of neurological disorders commonly associated with the neuronal
malfunction leading to generation of seizures. Recent reports point to a possible contribution …

Stress-associated molecular and cellular hippocampal mechanisms common for epilepsy and comorbid depressive disorders

NV Gulyaeva - Biochemistry (Moscow), 2021 - Springer
The review discusses molecular and cellular mechanisms common to the temporal lobe
epileptogenesis/epilepsy and depressive disorders. Comorbid temporal lobe epilepsy and …

Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy

E Ren, G Curia - International Journal of Molecular Sciences, 2021 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …