A library of monoclonal antibodies (MoAbs) has been produced against a human
hepatocellular carcinoma (HCC) cell line designated FOCUS in order to study the antigenic …

Loss of repressor element 1 silencing transcription factor (REST) occurs in 20% of breast
cancers and correlates with a poor patient prognosis. However, the molecular basis for …

Several growth-promoting signaling pathways have tight molecular connections with
metabolic-related signal transduction systems. By controlling these pathways, cancer cells …

Previous studies have shown that insulin receptor substrate (IRS) 1 and IRS2 mediate
proliferative and antiapoptotic signaling through the IL-4R in 32D cells; however their role in …

The insulin receptor substrate (IRS) family of signaling molecules is expressed in
lymphocytes, although their functions in these cells is largely unknown. To investigate the …

The incidence of breast cancer may be running parallel to the high insulin levels that occur
with diabetes mellitus and atherosclerosis. Estrogens are known to increase the risk of …

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Aims/hypothesis. Although both increased cell growth and impaired insulin signalling have
been associated with diabetes, this association has not been investigated. Insulin-like …

A line of double-transgenic mice that develop neoplasms arising primarily in the pancreas
was established. In these mice, the oncogene SV40 T antigen (Tag) was detected in the …

There is evidence that the insulin-like growth factor-I (IGF-I) receptor is required for
transformation by a variety of viral and cellular oncogenes in a mouse embryo fibroblast …